Protein Modification Reagents
Cayman Chemical DMPE-MPEG 2000 50mg
A PEGylated form of DMPE; has been used in the synthesis of NLCs for use in ocular administration of ciprofloxacin
Medchemexpress LLC M-PEG2-Tos | 50586-80-6 | 274.33 g/mol | C12H18O5S | 10 G
m-PEG2-Tos is a PEG-derived, uncleavable linker used for bioconjugation in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs). It provides a short PEG spacer that improves solubility and stability between the targeting moiety and payload.
- Uncleavable PEG-based linker suitable for ADC and PROTAC construction.
- Short PEG spacer improves solubility and reduces aggregation.
- Molecular weight 274.33 g/mol, formula C12H18O5S.
- CAS number 50586-80-6.
- Available in laboratory pack sizes, including 10 g.
eMolecules 2055198-05-3 | Sulfo DBCO-PEG4-amine | Broadpharm | MFCD30458045 | 674.770 | C32H42N4O10S | 90.000 | NCCOCCOCCOCCOCCC(=O)NCC(C(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)S(O)(=O)=O | 25mg | 340377134
Sulfo DBCO-PEG4-amine | Broadpharm | 2055198-05-3 | MFCD30458045 | 674.770 | C32H42N4O10S | 90.000 | NCCOCCOCCOCCOCCC(=O)NCC(C(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)S(O)(=O)=O | 25mg | 340377134
Medchemexpress LLC DBCO-PEG4-maleimide | 1480516-75-3 | 95.9% | 674.74 g/mol | C36H42N4O9 | 10 MG
DBCO-PEG4-maleimide is a bifunctional PEG4 linker bearing a strained dibenzocyclooctyne (DBCO) and a terminal maleimide. It enables site-selective conjugation by combining thiol-maleimide chemistry with strain-promoted azide-alkyne cycloaddition, making it suitable for antibody-drug conjugate assembly and other bioconjugation workflows.
- Enables site-selective conjugation via thiol-maleimide coupling and SPAAC
- Contains a PEG4 spacer for increased solubility and reduced steric hindrance
- Liquid form, colorless to light yellow, suitable for solution-phase reactions
- High reported purity supports reproducible conjugation results
- Soluble in DMSO at approximately 50 mg/mL; ultrasonic assistance may be required
- Store protected from light; keep frozen under inert atmosphere for long-term storage
Medchemexpress LLC DBCO-PEG5-NHS ester | 2144395-59-3 | 95.0% | 693.74 | C36H43N3O11 | 25 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG linker with an N-hydroxysuccinimide (NHS) ester reactive group. It acts as a click chemistry reagent enabling strain-promoted alkyne-azide cycloaddition (SPAAC) and serves as a PEG-based linker for the synthesis of PROTACs and antibody-drug conjugates (ADCs).
- Enables copper-free click chemistry (SPAAC) with azide-containing molecules.
- Reactive NHS ester couples efficiently to primary amines, such as lysine residues or aminosilane-coated surfaces.
- PEG5 spacer provides flexibility and reduces steric hindrance at conjugation sites.
- Suitable for linker design in PROTAC and ADC synthesis.
- Available in small milligram pack sizes for research-scale applications.
Medchemexpress LLC Dbco-PEG5-NHS ester | 2144395-59-3 | 693.74 g/mol | C36H43N3O11 | 50 MG
Dbco-PEG5-NHS ester is a heterobifunctional, PEG-based bioorthogonal linker that combines a dibenzocyclooctyne (DBCO) moiety for strain-promoted alkyne-azide cycloaddition with an N-hydroxysuccinimide (NHS) ester for selective coupling to primary amines. It is intended for use in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and for copper-free click chemistry and surface labeling.
- Enables copper-free click conjugation to azide-containing molecules via the DBCO group.
- Allows rapid amine coupling through the NHS ester at pH 7-9.
- PEG5 spacer improves solubility and reduces steric hindrance.
- Supplied as a small-scale reagent suitable for research and development work.
Medchemexpress LLC 2,5,8,11-Tetraoxatridecane, 13-azido- | 606130-90-9 | 98.0% | C9H19N3O4 | 50 MG
2,5,8,11-Tetraoxatridecane, 13-azido- is a chemical compound with a molecular weight of 233.26. It appears as a colorless to light yellow liquid and is intended for research use only. This product has been tested and complies with the given specifications.
- Colorless to light yellow liquid appearance
- Molecular weight of 233.26
- Suitable for research applications
- Storage in pure form at -20°C for 3 years
- Storage in solvent at -80°C for 6 months
- Storage in solvent at -20°C for 1 month
Medchemexpress LLC Dbco-peg4-nhs ester | 1427004-19-0 | 99.00% | C34H39N3O10 | 100 MG
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent contains a DBCO group, enabling it to undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs themselves consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a specific protein, thereby exploiting the intracellular ubiquitin-proteasome system for selective protein degradation.
- Can be used in the synthesis of PROTACs.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition.
- Exploits the intracellular ubiquitin-proteasome system.
- Enables selective degradation of target proteins.
Medchemexpress LLC (S,R,S)-AHPC-PEG4-NH2 hydrochloride | 2064292-52-8 | 98.2% | 700.29 g/mol | C32H50ClN5O8S | 50 MG
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase VHL ligand-linker conjugate used as a PROTAC building block. It combines an (S,R,S)-configured AHPC VHL ligand with a four-unit PEG linker terminating in a primary amine, providing a conjugation handle for assembling bifunctional degraders.
- VHL ligand core for recruiting the VHL E3 ligase.
- Four-unit PEG linker imparts flexibility and improves solubility.
- Terminal primary amine enables straightforward conjugation to warheads or linkers.
- High purity suitable for research synthesis (≈98.2%).
- Water solubility up to 50 mg/mL (ultrasonic may be required) for formulation convenience.
- Supplied as a hydrochloride salt to aid stability and handling.
- Intended for use as a PROTAC intermediate in targeted protein degradation research.
Medchemexpress LLC Carboxy-PEG4-phosphonic acid | 1623791-69-4 | 96.0% | C11H23O9P | 100 MG
Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are compounds with two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other the protein of interest. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
eMolecules 2112731-44-7 | N-Boc-PEG9-alcohol | Broadpharm | MFCD30723250 | 513.625 | C23H47NO11 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 343283756
N-Boc-PEG9-alcohol | Broadpharm | 2112731-44-7 | MFCD30723250 | 513.625 | C23H47NO11 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 343283756